I can see your point on Sokratis. Would be a nightmare if he picked up an injury tonight.
Who would you start alongside koscielny?
It partly depends on what Emery is planning to do at CB for the Southampton game. If he thinks Monreal is going to play there with Koscielny, which seems quite likely, I would probably give them both the first 45-60 minutes of this game as a CB partnership, then bring on Medley & Lichsteiner to give them a try at CB, also try Elneny at CB for part of his 90 minutes. His other options for CB versus Southampton I guess will be Lichsteiner, Kolasinac, Medley, Elneny, Jenkinson???
Something along those lines. Test his available CBs for Southampton while attempting to avoid injury or fatigue, and without overloading them with too many complicated changes in personnel/formation.
Sokratis needs to be kept injury free for the Sp**s cup game and beyond.
If ESR is injured, I'd probably go with Özil or the best available academy option rather than risking Mhki/Iwobi, given that would mean ESR in addition to Welbeck & Ramsey.
Cech
Jenks - Kos - Monreal - Bramhall
Elneny-AMN
ESR Willock Saka
Nketiah